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Alessandra Cucinelli

Post Doc
Post Doc
Brain Development and Disease
Alessandra Cucinelli
Research center
About

Neuroscientist and preclinical researcher with expertise in behavioral neuroscience, neuropharmacology, molecular biology, and translational research, with a particular focus on inhibitory neurotransmission and neurological disorders.

I obtained my BSc in Biotechnology from the University of Pisa in 2019 (110/110 cum laude) and my MSc in Neuroscience from the University of Pisa in 2021 (110/110). In 2026, I completed a PhD in Neuroscience at the University of Genoa and the Italian Institute of Technology (IIT), under the supervision of Dr. Laura Cancedda.

I am currently a Postdoctoral Researcher in the Brain Development and Diseases Lab at the Italian Institute of Technology (IIT).

My research focuses on:

• Preclinical studies of neurological and neurodevelopmental disorders using rodent models

• Behavioral phenotyping and assessment of cognitive and neuropsychiatric alterations

• Neuropharmacological studies and preclinical characterization of novel therapeutic compounds

• Molecular, biochemical, and histological analyses of brain tissue

• In vivo drug administration and experimental procedures, including stereotaxic surgery and viral delivery

• Investigation of GABAergic neurotransmission, chloride homeostasis, and inhibitory circuit function

During my PhD, my research focused on the mechanisms underlying age-related cognitive decline, particularly the role of altered hippocampal GABAergic signaling and chloride regulation. I investigated the therapeutic potential of modulating the KCC2 chloride transporter through an integrated approach combining behavioral studies, molecular analyses, pharmacology, imaging, and translational investigations.

My current research focuses on inhibitory circuit dysfunction in neurodevelopmental disorders and on the preclinical characterization of novel pharmacological approaches for neurological diseases. My work combines mechanistic research with translational pharmacology to understand disease-related alterations in neuronal function and identify potential therapeutic strategies.



Education

Title: PhD in Neuroscience
Institute: University of Genoa
Location: Istituto Italiano di Tecnologia
Country: Italy
From: 2022 To: 2025

Title: Master's Degree in Neuroscience
Institute: University of Pisa
Location: PISA
Country: Italy
From: 2019 To: 2021

Title: Bechelor's Degree in Biotechnology
Institute: University of Pisa
Location: Pisa
Country: Italy
From: 2016 To: 2019

All Publications
2026
Cucinelli A.
Reducing GABAAR over-inhibition via KCC2 modulation restores cognition and benzodiazepine sensitivity in elderly mice
PhD Thesis Book
2026
Morelli G., Visintin G., Gelli E., Serani A., Bartolucci M., Uccella S., D'Apruzzo M., Preiti D., Chellali M.M., Cucinelli A., Rastogi M., Falappa M., Scalabrini A., Turecki G., Petretto A., Tucci V., Cancedda L.
Traumatic life experiences during critical periods lead to diverse developmental trajectories
Cell Reports Medicine, vol. 7, (no. 6)
2025
Cucinelli A., Colombi I., Piccardi F., Bolla M., La Bella T., Gaeta A., Ruffolo G., Borgogno M., Ronzitti G., Palma E., De Vivo M., Contestabile A., Savardi A., Cancedda L.
KCC2 as a novel pharmacological target for reversing cognitive impairment in elderliness.
Gordon Research Seminar-Biology of Ageing
Poster Conference
2025
Castellani G., Ciampoli M., Benedetti A., Ferretti V., Trigilio G., Barcik W., Busnelli M., Contarini G., Paolini C., Devroye C., Aburto M.R., Cucinelli A., Antonelli F., Maltese F., Braccia C., Pacinelli G., Manago F., Rodriguez-Gimeno A., Mazzarella M.A., Sannino S., Albanesi E., Nigro M., Bertozzi F., Armirotti A., De Martin S., Chini B., Papaleo F.
Oxytocin seals the blood-brain barrier, improving 22q11.2 deletion syndrome trajectories
Brain, vol. 148, (no. 9), pp. 3184-3198
Dissemination
2024
Cucinelli A.
Come nasce un farmaco: dal laboratorio fino alle nostre case
Giornata Internazionale sulla Disabilità
Public Event
Oral presentations
2025
Cucinelli A., Colombi I., Piccardi F., Bolla M., La Bella T., Gaeta A., Ruffolo G., Borgogno M., Ronzitti G., Palma E., De Vivo M., Contestabile A., Savardi A., Cancedda L.
KCC2 as a novel pharmacological target for reversing cognitive impairment in elderliness.
Gordon Research Seminar-Biology of Ageing
Conference
Awards and Achievements
2025
Cucinelli A., Colombi I., Piccardi F., Bolla M., La Bella T., Ruffolo G., Gaeta A., Ronzitti G., Palma E., Contestabile A., Savardi A., Cancedda L.
Award "Best Poster Presentation"
2025
Cucinelli A., Colombi I., Piccardi F., Bolla M., La Bella T., Gaeta A., Ruffolo G., Borgogno M., Ronzitti G., Palma E., De Vivo M., Contestabile A., Savardi A., Cancedda L.
Award "Best Poster Presentation"
2025
Cucinelli A., Colombi I., Piccardi F., Bolla M., La Bella T., Gaeta A., Ruffolo G., Borgogno M., Ronzitti G., Palma E., De Vivo M., Contestabile A., Savardi A., Cancedda L.
Award "Best Talk"
2024
Visintin G., Cucinelli A., Khan A., Colombo G.
Proposal selected for the Researchers’ Night event, Genoa, Italy